Whilst some artists use the stroke of a brush or make lines with a pencil, Karle had other plans she is a bioartist. Using living materials such as human stem cells, she creates art that grows and has it’s very own heartbeat. Karle creates enticing works that go beyond its futuristic appearance, they are projects that one day may be used as blueprints for possible solutions in the medical realm. Technology can be seen as a negative thing, some believing it will lead us down a rabbit hole where humans lose control, but Karle chooses to see the good in technology. She uses the combination of art and science to create a healthy relationship between humanity and technology, one that heals and restores. Growing up in a lab with her mother as well as visiting shrines and churches with her grandmother has greatly influenced the duality of her work. She presents her art as both relics and scientific specimens, a combination of something new and futuristic, but also something that is familiar with humanity.